Haplotype analysis of ADAM33 polymorphisms in asthma: A pilot study
نویسندگان
چکیده
منابع مشابه
ADAM33 gene polymorphisms in Southwestern Iranian patients with asthma
Objective(s): Asthma, the most frequent chronic respiratory disease, results from a complex interaction between multiple genes and environmental factors. To date, more than 100 candidate genes and single nucleotide polymorphisms (SNPs) have been reported to be associated with asthma. One of the discovered genes related to asthma is ADAM33. However, the relationship between ADAM33 gene polymorph...
متن کاملAssociation of ADAM33 gene polymorphisms with allergic asthma
Objective(s): Asthma results from the interaction between genetic and environmental factors. ADAM33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. Materials and Methods: This is a case-control study, where four SNPs S1 (rs3918396), T1 (rs2280091), T2 (rs2280090), V4 (rs2787094) of ADAM33 gene have been assessed in patients with allergic asthma and normal con...
متن کاملADAM33 polymorphisms and phenotype associations in childhood asthma.
BACKGROUND A disintegrin and metalloproteinase (ADAM) 33 has been implicated as an asthma susceptibility gene by using a positional cloning approach. However, genetic linkage of asthma phenotypes to chromosome 20p13 (the location of ADAM33) has not been observed in most asthma genome scans, and it is unclear whether these associations with ADAM33 are broadly generalizable. OBJECTIVE To examin...
متن کاملContribution of ADAM33 polymorphisms to the population risk of asthma.
BACKGROUND ADAM 33 is the first gene identified as a candidate for asthma by positional cloning techniques, with association studies reaching impressive statistical significance. It has a postulated role in myogenesis, airway modelling, and signalling via protein shedding. Concerns over the methodology of the initial study have led to several attempts at replication, with inconsistent results. ...
متن کاملAssociation of ADAM33 gene polymorphisms with allergic asthma
OBJECTIVES Asthma results from the interaction between genetic and environmental factors. ADAM33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. MATERIALS AND METHODS This is a case-control study, where four SNPs S1 (rs3918396), T1 (rs2280091), T2 (rs2280090), V4 (rs2787094) of ADAM33 gene have been assessed in patients with allergic asthma and normal contro...
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ژورنال
عنوان ژورنال: Indian Journal of Medical Research
سال: 2019
ISSN: 0971-5916
DOI: 10.4103/ijmr.ijmr_698_17